When it comes to discussing intestinal biopsies, the same question seems to be asked over and over again: "Do I need full thickness or partial thickness biopsies to get a diagnosis"? While working in general practice I asked this question of many Pathologists and Internists. The answer was as variable as the personalities the question was being posed to. At times the opinion would be that full thickness biopsies were really the only way to confidently differentiate betwee