When it comes to discussing intestinal biopsies, the same question seems to be asked over and over again: "Do I need full thickness or partial thickness biopsies to get a diagnosis"? While working in general practice I asked this question of many Pathologists and Internists. The answer was as variable as the personalities the question was being posed to. At times the opinion would be that full thickness biopsies were really the only way to confidently differentiate between diseases that can look similar (think Inflammatory Bowel Disease vs. Lymphoma). Just as quickly as that seemed to be "gospel", the opinions would change and partial thickness biopsies were now the best (and least inva
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